La Mesa vacation rentals | Houfy — Book Direct

La Mesa vacation rentals

Vacation rentals in La Mesa by owner — compare homes, condos and cabins, message verified hosts and book direct. See every charge before you pay.

Top-Rated Vacation Homes in La Mesa

Browse the highest rated vacation properties in La Mesa.

Private, Charming Cottage! Perfect for Long Stays!

1 bd·1 ba
5· 49

$547.35 USD total for 3 nights

Nov 1 – 4, 2026

My stay here was the best Air BnB has to offer. 5 stars is not enough to rate this home! I did not want to leave. Almost everything was perfect. If there was any issues, they were solved in minutes (or at least in an hour). Shane made me feel right at home. I have never met a nicer person. I am going to say it...I luv u! ...lol. Everything you need is provided. From snacks and coffee to carpet cleaning, everything was perfect! I could go on and on about my stay here, but that would take a whole day to type it out! If you are looking to stay ANYWHERE in San Diego county, STAY HERE! Wherever you need to be is just a short drive away. Freeway access to just about any direction you need to go. The trolley station is close by and can take you in every direction if you don't want to drive. Ask Shane about her fur babies! Miniature HUGGING donkeys and fainting goats! Thank you for being such an incredible host. Hopefully we will meet up again!
A. · Stay May 2026

Welcoming Bungalow with 2nd BR/Office & Chef's Kitchen

2 bd·1 ba
5· 43

$645.00 USD total for 3 nights

Oct 25 – 28, 2026

My husband and I needed a place to stay temporarily while our condo was being renovated. It was estimated to be a six week stay and we needed space for 2 home offices, 2 cars and a home away from home feeling. We found all that and more at Shane's Nest Adventure. Shane was a fantastic host. She was responsive, provided us with everything we needed and offered flexibility because of the uncertain nature of our timeline. The house was exactly as described and pictured. Because we're local she let us go over to look at it before we made our reservation since we were concerned about its functionality for a longer stay. The rooms have windows on multiple sides that let in a TON of natural light which is really important to us. The bed was so comfortable we decided to replace our mattress with the same one as part of our renovation. There are nearby restaurants and the Village of La Mesa with a terrific farmers market on Fridays. We are grateful to Shane for her incredible hospitality!
V. · Stay May 2024

Chic, Playful Boho Bungalow Near Everything!

1 bd·1 ba
5· 27

$547.35 USD total for 3 nights

Oct 26 – 29, 2026

We stayed at Shane's place for one month to welcome our newborn in San Diego. If I could give more than five stars, I would. 1st, the house: it was cozy and it was perfect for our situation. A cute fenced-in yard within a larger corner lot with its own parking spot and built in a way that gave it privacy. The washer-dryer in the bedroom gave us immediate access to laundry for those sleepless nights of feedings. It had a working kitchenette. And the island doubled as a kitchen and office space - I made it work. Big TV with cable and all the streaming services (login to your own account). The neighborhood is quiet; the house is close to the freeway and central to shopping and San Diego sightseeing. 2nd, Shane: was super communicative, flexible, and welcoming in a way that made our anxious journey easier. We had a welcome basket of goodies. She bought us a vacuum. She left us a precious handmade baby gift! Above and beyond what I have experienced with AirBnB hosts. Thank you.
O. · Stay September 2023

Recommended Homes in La Mesa

Handpicked properties we think you'll love in La Mesa.

$720.30 USD total for 3 nights

Oct 27 – 30, 2026

$1,277.00 USD total for 3 nights

Oct 19 – 22, 2026

$1,404.59 USD total for 3 nights

Oct 19 – 22, 2026

Downtown La Mesa Gem

3 bd·2 ba

$553.35 USD total for 3 nights

Oct 19 – 22, 2026

$1,211.70 USD total for 3 nights

Oct 24 – 27, 2026

$3,397.80 USD total for 4 nights

Oct 19 – 23, 2026

$785.00 USD total for 3 nights

Oct 26 – 29, 2026

Best Time to Visit La Mesa

La Mesa offers warm temperatures year-round, best from April to June. Experience highs from 65°F in January to 88°F in August. Enjoy sunny days and mild evenings.

The best time to visit La Mesa is April to November, when the weather is at its best. For lower prices and fewer crowds, November to February is the best time to book.

Best weatherApr – Nov
Best valueNov – Feb

OctNow

77°F25°C

Rainfall Low

Demand Mid

Nov

71°F22°C

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Demand Low

Dec

66°F19°C

Rainfall Moderate

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Jan

65°F18°C

Rainfall Moderate

Demand Low

Feb

66°F19°C

Rainfall Moderate

Demand Low

Mar

68°F20°C

Rainfall Moderate

Demand Mid

Apr

71°F22°C

Rainfall Low

Demand Mid

May

73°F23°C

Rainfall Low

Demand Mid

Jun

76°F24°C

Rainfall Low

Demand Peak

Jul

82°F28°C

Rainfall Low

Demand Peak

Aug

88°F31°C

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Demand Peak

Sep

85°F29°C

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Demand Mid

Similar vacation rentals near La Mesa

Homes within 60 miles of La Mesa, from verified hosts.

Red Barn Ranch- Luxury Retreat & Farm Stay

7 bd·5 ba
5· 8

$3,903.00 USD total for 3 nights

Oct 19 – 22, 2026

MISSION BEACH SURF LODGE in ️ of MISSION BEACH!!

2 bd·1 ba
4.96· 191

$1,055.71 USD total for 3 nights

Oct 26 – 29, 2026

Mountain Retreat

4 bd·3 ba
5· 28

$2,242.50 USD $1,879.50 USD total for 3 nights

Oct 19 – 22, 2026

New Remodeled 2 BR Close to Zoo and Restaurants

2 bd·1 ba
4.73· 456

$431.16 USD total for 3 nights

Oct 19 – 22, 2026

California Cool 1 br House Walk to Restaurant Bars

1 bd·1 ba
4.71· 356

$352.56 USD total for 3 nights

Nov 1 – 4, 2026

Casa Pacifica West

2 bd·1 ba
4.91· 431

Cozy Apartment in Historic SD Walk to Restaurants

1 bd·1 ba
4.64· 308

$340.24 USD total for 3 nights

Oct 19 – 22, 2026

Pacific/Mission Beach/Bay/CrownPtShores/Primo LOCA

4 bd·2 ba
4.56· 273

$1,902.95 USD total for 3 nights

Oct 19 – 22, 2026

Steps to the Ocean+Village Beach Home w Hot Tub

3 bd·2½ ba
5· 366

$1,473.25 USD total for 3 nights

Oct 25 – 28, 2026

Upscale Studio Close to Balboa Park & Zoo

0 bd·1 ba
4.76· 273

$438.04 USD total for 3 nights

Oct 21 – 24, 2026

MissionBeach/OCEAN&BAYFront/HOTub/Sunrise/SETViews

1 bd·1 ba
4.61· 228

$999.00 USD total for 3 nights

Oct 19 – 22, 2026

Family Villa • Near Legoland & Beach • Dogs Free

4 bd·3 ba
4.93· 235

$1,538.90 USD total for 3 nights

Oct 25 – 28, 2026

Explore near La Mesa

Cities and towns within driving distance of La Mesa, each bookable direct with the host.

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